RiverPLA Leads Innovation in Hyaluronic Acid Production from Dairy Waste

We are pleased to announce the award of the Crea y Valida 2024 Project, focused on the production of Hyaluronic Acid from dairy waste.

At RiverPLA, we are proud to be pioneers in Chile and throughout Latin America in the development of this valuable product, which is highly demanded in both the aesthetic and pharmaceutical industries. This achievement represents a significant step towards sustainability and innovation in our sector.

Hyaluronic Acid is a natural compound found in the human body and is known for its hydrating and rejuvenating properties. Its production from dairy waste not only offers a sustainable solution but also opens new opportunities for the dairy industry, allowing the valorization of by-products that were previously considered waste.

Project Details

The project, titled “RIVERHA: OPTIMIZATION AND SCALING OF HYALURONIC ACID PRODUCTION FROM WHEY,” aims to develop a high-efficiency production method through bacterial biosynthesis with Streptococcus strains cultivated in whey. This method seeks to achieve a 20% yield of hyaluronic acid production from dry whey.

Duration

The project duration is 24 months, with the possibility of an extension of up to 6 additional months.

Main Activities

The project activities include:

• Prototyping: Development of prototypes for the standardization of the culture medium with whey and evaluation of Streptococcus thermophilus strains to optimize bacterial biomass production and hyaluronic acid biosynthesis.
• Experimental Tests: Standardization of protocols for the precipitation and isolation of hyaluronic acid, analysis of its purity and molecular weight, and drawing conclusions about its performance in new scaling bioprocesses.
• Intellectual Property Protection: Expert advice to develop an intellectual property protection strategy and operate a licensing-based business model.
• Technical Validation: Development of a pre-industrial scaling pilot using a 100-liter bioreactor to optimize biosynthesis efficiency as production scale increases.
• Financing Strategy: Seeking funding in Spain to strengthen and develop a process licensing strategy focused on the international expansion of the high-efficiency production method.

Acknowledgments

We thank the talented RiverPLA team, whose effort and dedication were fundamental to the application and award of this project. This is just the beginning of a new era for our company and the market. We continue to move forward with commitment and enthusiasm!

Official Documents

In accordance with the obligations established by Electronic Resolution (E) No. 413 of 2024 of the InnovaChile Committee, the following official documents related to the project are attached:

1. Subsidy Notification Letter 24CVC-264604
2. Electronic Exempt Innovation Subsidy Resolution 24CVC-26460
3. Resources Received
4. Financial Status Report
5. List of Directors and Administrators
6. General Balance Sheet 2022
7. General Balance Sheet 2023

At RiverPLA, we are committed to innovation and sustainability. This project not only positions us as leaders in the production of hyaluronic acid from dairy waste but also contributes to the valorization of by-products and the development of sustainable solutions for the industry.

Thank you for joining us on this exciting journey towards the future of innovation and sustainability!